The Alzheimer’s Disease Genetics Consortium (ADGC) and and the International Genomics of Alzheimer’s Project (IGAP) performed the largest genetic wide association study (GWAS) to date to discover risk loci for LOAD. Their meta-analysis implicates Abeta, Tau, immunity and lipid processing. The paper on Alzheimer’s disease genetic association has been published on bioRxiv and can be found here.

 

Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

Brian W. Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C. Bis, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alex Amlie-Wolf, Celine Bellenguez, Aura Frizatti, Vincent Chouraki, Alzheimer’s Disease Genetics Consortium (ADGC), European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in Alzheimer’s Disease Consortium (GERAD/PERADES), Helena Schmidt, Hakon Hakonarson, Ron Munger, Reinhold Schmidt, Lindsay A. Farrer, Christine Van Broeckhoven, Michael C. O’Donovan, Anita L. Destefano, Lesley Jones, Jonathan L. Haines, Jean-Francois Deleuze, Michael J. Owen, Vilmundur Gudnason, Richard P. Mayeux, Valentina Escott-Price, Bruce M. Psaty, Agustin Ruiz, Alfredo Ramirez, Li-San Wang, Cornelia M. van Duijn, Peter A. Holmans, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D. Schellenberg, Jean-Charles Lambert, Margaret A. Pericak-Vance
bioRxiv 294629; doi: https://doi.org/10.1101/294629

 

 

 

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